python mail smtplib

#!/usr/bin/env python
# _*_ coding: utf-8 _*_
# @Time     : 2017/11/1 15:13
# @Author   : otfsenter
# @File     : t123.py

import smtplib
from email.mime.multipart import MIMEMultipart
from email.mime.text import MIMEText

import my_key

me = 'mail_address'
you = ['mail_address1', 'mail_address2']
text_file = '2.txt'

msg = MIMEMultipart()
msg['Subject'] = 'Subject'
msg['From'] = me
msg['To'] = ','.join(you)

message = MIMEText('fp.read()')
msg.attach(message)

files = MIMEText(open('t.xls', 'rb').read(), 'base64', 'utf-8')
files["Content-Type"] = 'application/octet-stream'
files["Content-Disposition"] = 'attachment;filename="t.xls"'
msg.attach(files)

s = smtplib.SMTP('mail_host', 25)
s.login(my_key.my_account, my_key.my_password)
s.sendmail(me, you, msg.as_string())
s.quit()