解决方法一: 前台按钮: <asp:Button ID="Button1" runat="server" OnClick="Button1_Click" Text="Button" OnClientClick="this.form.submit();this.disabled=true" UseSubmitBehavior="False" /> 后台代码: protected void Page_Load( object sender, EventArgs e ) { if (Page.IsPostBack) { Button1.Attributes.Add("disabled", "disabled"); } } 关键是红色部分OnClientClick="this.form.submit();this.disabled=true" UseSubmitBehavior="False" 。 解决方法二: this.btnSubmit.Attributes["onclick"] = this.GetPostBackEventReference(this.btnSubmit) + ";this.disabled=true;"; //防止重复提交