https://www.genenames.org/data/genegroup/#!/group/588
Major histocompatibility complex: The major histocompatibility complex ( MHC ) is a set of cell surface molecules encoded by a large gene family in all vertebrates. MHC molecules mediate interactions of leukocytes, also called white blood cells (WBCs), which are immune cells, with other leukocytes or body cells. MHC determines compatibility of donors for organ transplant as well as one's susceptibility to an autoimmune disease via crossreacting immunization. [Source: Wikipedia]
主要组织相容性复合物：主要组织相容性复合物（MHC）是由所有脊椎动物中的大基因家族编码的一组细胞表面分子。 MHC分子介导白细胞（也称为白血细胞（WBC），其是免疫细胞）与其他白细胞或体细胞的相互作用。 MHC确定供体对器官移植的兼容性以及通过交叉反应免疫接种对自身免疫疾病的易感性。
P01891的定位结构域，由HLA-A基因编码，是该组内的一个示例基因。 [来源：Pfam＆UniProt]
包含44个基因：
| HGNC ID (gene) | Approved symbol | Approved name | Previous symbols | Synonyms | Chromosome |
|---|---|---|---|---|---|
| HGNC:4931 | HLA-A | major histocompatibility complex, class I, A | 6p22.1 | ||
| HGNC:4932 | HLA-B | major histocompatibility complex, class I, B | AS | 6p21.33 | |
| HGNC:4933 | HLA-C | major histocompatibility complex, class I, C | HLA-JY3,D6S204,PSORS1 | 6p21.33 | |
| HGNC:4934 | HLA-DMA | major histocompatibility complex, class II, DM alpha | D6S222E,RING6 | 6p21.32 | |
| HGNC:4935 | HLA-DMB | major histocompatibility complex, class II, DM beta | D6S221E,RING7 | 6p21.32 | |
| HGNC:4936 | HLA-DOA | major histocompatibility complex, class II, DO alpha | HLA-DZA,HLA-DNA | HLA-D0-alpha | 6p21.32 |
| HGNC:4937 | HLA-DOB | major histocompatibility complex, class II, DO beta | 6p21.32 | ||
| HGNC:4938 | HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | HLA-DP1A | 6p21.32 | |
| HGNC:4939 | HLA-DPA2 | major histocompatibility complex, class II, DP alpha 2 (pseudogene) | HLA-DP2A | 6p21.32 | |
| HGNC:19393 | HLA-DPA3 | major histocompatibility complex, class II, DP alpha 3 (pseudogene) | 6p21.32 | ||
| HGNC:4940 | HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 | HLA-DP1B | 6p21.32 | |
| HGNC:4941 | HLA-DPB2 | major histocompatibility complex, class II, DP beta 2 (pseudogene) | HLA-DP2B | DP2B,DPB2 | 6p21.32 |
| HGNC:4942 | HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | HLA-DQA | CELIAC1 | 6p21.32 |
| HGNC:4943 | HLA-DQA2 | major histocompatibility complex, class II, DQ alpha 2 | HLA-DXA | 6p21.32 | |
| HGNC:4944 | HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | HLA-DQB | IDDM1,CELIAC1 | 6p21.32 |
| HGNC:4945 | HLA-DQB2 | major histocompatibility complex, class II, DQ beta 2 | HLA-DXB | 6p21.32 | |
| HGNC:4946 | HLA-DQB3 | major histocompatibility complex, class II, DQ beta 3 | HLA-DVB | D6S205,D6S205E,DVB,DQB3 | 6p21.3 |
| HGNC:4947 | HLA-DRA | major histocompatibility complex, class II, DR alpha | HLA-DRA1 | 6p21.32 | |
| HGNC:4948 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | HLA-DR1B | 6p21.32 | |
| HGNC:4950 | HLA-DRB2 | major histocompatibility complex, class II, DR beta 2 (pseudogene) | HLA-DR2B | 6p21.3 alternate reference locus | |
| HGNC:4951 | HLA-DRB3 | major histocompatibility complex, class II, DR beta 3 | HLA-DR3B | 6p21.3 alternate reference locus | |
| HGNC:4952 | HLA-DRB4 | major histocompatibility complex, class II, DR beta 4 | HLA-DR4B | 6p21.3 alternate reference locus | |
| HGNC:4953 | HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 | 6p21.32 | ||
| HGNC:4954 | HLA-DRB6 | major histocompatibility complex, class II, DR beta 6 (pseudogene) | 6p21.32 | ||
| HGNC:4955 | HLA-DRB7 | major histocompatibility complex, class II, DR beta 7 (pseudogene) | 6p21.3 alternate reference locus | ||
| HGNC:4956 | HLA-DRB8 | major histocompatibility complex, class II, DR beta 8 (pseudogene) | 6p21.3 alternate reference locus | ||
| HGNC:4957 | HLA-DRB9 | major histocompatibility complex, class II, DR beta 9 (pseudogene) | HLA-DRB1L,HLA-DR1BL | D6S206,D6S206E | 6p21.32 |
| HGNC:4962 | HLA-E | major histocompatibility complex, class I, E | 6p22.1 | ||
| HGNC:4963 | HLA-F | major histocompatibility complex, class I, F | 6p22.1 | ||
| HGNC:4964 | HLA-G | major histocompatibility complex, class I, G | 6p22.1 | ||
| HGNC:4965 | HLA-H | major histocompatibility complex, class I, H (pseudogene) | 6p22.1 | ||
| HGNC:4967 | HLA-J | major histocompatibility complex, class I, J (pseudogene) | HLA-CDA12,D6S203 | CDA12,HLA-59 | 6p22.1 |
| HGNC:4969 | HLA-K | major histocompatibility complex, class I, K (pseudogene) | HLAK,HLA70 | HLA-70 | 6p22.1 |
| HGNC:4970 | HLA-L | major histocompatibility complex, class I, L (pseudogene) | HLA92,HLAL | HLA-92 | 6p22.1 |
| HGNC:19406 | HLA-N | major histocompatibility complex, class I, N (pseudogene) | HLA-30 | 6p22.1 | |
| HGNC:21196 | HLA-P | major histocompatibility complex, class I, P (pseudogene) | C6orf101,HLA-90 | dJ377H14.3 | 6p22.1 |
| HGNC:19395 | HLA-S | major histocompatibility complex, class I, S (pseudogene) | HLA-17 | 6p21.33 | |
| HGNC:23478 | HLA-T | major histocompatibility complex, class I, T (pseudogene) | HLA-16 | 6p22.1 | |
| HGNC:23477 | HLA-U | major histocompatibility complex, class I, U (pseudogene) | HLA-21 | Em:AB023056.13 | 6p22.1 |
| HGNC:23482 | HLA-V | major histocompatibility complex, class I, V (pseudogene) | HLA-75 | dJ377H14.4 | 6p22.1 |
| HGNC:23425 | HLA-W | major histocompatibility complex, class I, W (pseudogene) | HLA-80 | 6p22.1 | |
| HGNC:19385 | HLA-X | major histocompatibility complex, class I, X (pseudogene) | 6p21.3 | ||
| HGNC:33913 | HLA-Y | major histocompatibility complex, class I, Y (pseudogene) | HLA-BEL/COQ/DEL | 6p21.33 | |
| HGNC:19394 | HLA-Z | major histocompatibility complex, class I, Z (pseudogene) | HLA-Z1 | 6p21.32 |
详细信息：
| HGNC ID | Approved symbol | Approved name | Status | Locus type | Previous symbols | Synonyms | Chromosome | NCBI Gene ID | Ensembl gene ID | Vega gene ID | Group ID | Group name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HGNC:4931 | HLA-A | major histocompatibility complex, class I, A | Approved | gene with protein product | 6p22.1 | 3105 | ENSG00000206503 | OTTHUMG00000130501 | 588 | Histocompatibility complex | ||
| HGNC:4932 | HLA-B | major histocompatibility complex, class I, B | Approved | gene with protein product | AS | 6p21.33 | 3106 | ENSG00000234745 | OTTHUMG00000031153 | 588 | Histocompatibility complex | |
| HGNC:4933 | HLA-C | major histocompatibility complex, class I, C | Approved | gene with protein product | HLA-JY3, D6S204, PSORS1 | 6p21.33 | 3107 | ENSG00000204525 | OTTHUMG00000031154 | 588 | Histocompatibility complex | |
| HGNC:4934 | HLA-DMA | major histocompatibility complex, class II, DM alpha | Approved | gene with protein product | D6S222E, RING6 | 6p21.32 | 3108 | ENSG00000204257 | OTTHUMG00000031173 | 588 | Histocompatibility complex | |
| HGNC:4935 | HLA-DMB | major histocompatibility complex, class II, DM beta | Approved | gene with protein product | D6S221E, RING7 | 6p21.32 | 3109 | ENSG00000242574 | OTTHUMG00000031176 | 588 | Histocompatibility complex | |
| HGNC:4936 | HLA-DOA | major histocompatibility complex, class II, DO alpha | Approved | gene with protein product | HLA-DZA, HLA-DNA | HLA-D0-alpha | 6p21.32 | 3111 | ENSG00000204252 | OTTHUMG00000031211 | 588 | Histocompatibility complex |
| HGNC:4937 | HLA-DOB | major histocompatibility complex, class II, DO beta | Approved | gene with protein product | 6p21.32 | 3112 | ENSG00000241106 | OTTHUMG00000031213 | 588 | Histocompatibility complex | ||
| HGNC:4938 | HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | Approved | gene with protein product | HLA-DP1A | 6p21.32 | 3113 | ENSG00000231389 | OTTHUMG00000031058 | 588 | Histocompatibility complex | |
| HGNC:4939 | HLA-DPA2 | major histocompatibility complex, class II, DP alpha 2 (pseudogene) | Approved | pseudogene | HLA-DP2A | 6p21.32 | 646702 | ENSG00000231461 | OTTHUMG00000031061 | 588 | Histocompatibility complex | |
| HGNC:19393 | HLA-DPA3 | major histocompatibility complex, class II, DP alpha 3 (pseudogene) | Approved | pseudogene | 6p21.32 | 267013 | ENSG00000237398 | OTTHUMG00000031063 | 588 | Histocompatibility complex | ||
| HGNC:4940 | HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 | Approved | gene with protein product | HLA-DP1B | 6p21.32 | 3115 | ENSG00000223865 | OTTHUMG00000031076 | 588 | Histocompatibility complex | |
| HGNC:4941 | HLA-DPB2 | major histocompatibility complex, class II, DP beta 2 (pseudogene) | Approved | pseudogene | HLA-DP2B | DP2B, DPB2 | 6p21.32 | 3116 | ENSG00000224557 | OTTHUMG00000031080 | 588 | Histocompatibility complex |
| HGNC:4942 | HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | Approved | gene with protein product | HLA-DQA | CELIAC1 | 6p21.32 | 3117 | ENSG00000196735 | OTTHUMG00000031106 | 588 | Histocompatibility complex |
| HGNC:4943 | HLA-DQA2 | major histocompatibility complex, class II, DQ alpha 2 | Approved | gene with protein product | HLA-DXA | 6p21.32 | 3118 | ENSG00000237541 | OTTHUMG00000031108 | 588 | Histocompatibility complex | |
| HGNC:4944 | HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | Approved | gene with protein product | HLA-DQB | IDDM1, CELIAC1 | 6p21.32 | 3119 | ENSG00000179344 | OTTHUMG00000031124 | 588 | Histocompatibility complex |
| HGNC:4945 | HLA-DQB2 | major histocompatibility complex, class II, DQ beta 2 | Approved | gene with protein product | HLA-DXB | 6p21.32 | 3120 | ENSG00000232629 | OTTHUMG00000031125 | 588 | Histocompatibility complex | |
| HGNC:4946 | HLA-DQB3 | major histocompatibility complex, class II, DQ beta 3 | Approved | unknown | HLA-DVB | D6S205, D6S205E, DVB, DQB3 | 6p21.3 | 3121 | ENSG00000226030 | OTTHUMG00000031127 | 588 | Histocompatibility complex |
| HGNC:4947 | HLA-DRA | major histocompatibility complex, class II, DR alpha | Approved | gene with protein product | HLA-DRA1 | 6p21.32 | 3122 | ENSG00000204287 | OTTHUMG00000031269 | 588 | Histocompatibility complex | |
| HGNC:4948 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | Approved | gene with protein product | HLA-DR1B | 6p21.32 | 3123 | ENSG00000196126 | OTTHUMG00000031196 | 588 | Histocompatibility complex | |
| HGNC:4950 | HLA-DRB2 | major histocompatibility complex, class II, DR beta 2 (pseudogene) | Approved | pseudogene | HLA-DR2B | 6p21.3 alternate reference locus | 3124 | ENSG00000227442 | OTTHUMG00000012608 | 588 | Histocompatibility complex | |
| HGNC:4951 | HLA-DRB3 | major histocompatibility complex, class II, DR beta 3 | Approved | gene with protein product | HLA-DR3B | 6p21.3 alternate reference locus | 3125 | ENSG00000196101 | OTTHUMG00000012609 | 588 | Histocompatibility complex | |
| HGNC:4952 | HLA-DRB4 | major histocompatibility complex, class II, DR beta 4 | Approved | gene with protein product | HLA-DR4B | 6p21.3 alternate reference locus | 3126 | ENSG00000227357 | OTTHUMG00000138996 | 588 | Histocompatibility complex | |
| HGNC:4953 | HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 | Approved | gene with protein product | 6p21.32 | 3127 | ENSG00000198502 | OTTHUMG00000031027 | 588 | Histocompatibility complex | ||
| HGNC:4954 | HLA-DRB6 | major histocompatibility complex, class II, DR beta 6 (pseudogene) | Approved | pseudogene | 6p21.32 | 3128 | ENSG00000229391 | OTTHUMG00000031028 | 588 | Histocompatibility complex | ||
| HGNC:4955 | HLA-DRB7 | major histocompatibility complex, class II, DR beta 7 (pseudogene) | Approved | pseudogene | 6p21.3 alternate reference locus | 3129 | ENSG00000227099 | OTTHUMG00000139002 | 588 | Histocompatibility complex | ||
| HGNC:4956 | HLA-DRB8 | major histocompatibility complex, class II, DR beta 8 (pseudogene) | Approved | pseudogene | 6p21.3 alternate reference locus | 3130 | ENSG00000233697 | OTTHUMG00000138997 | 588 | Histocompatibility complex | ||
| HGNC:4957 | HLA-DRB9 | major histocompatibility complex, class II, DR beta 9 (pseudogene) | Approved | pseudogene | HLA-DRB1L, HLA-DR1BL | D6S206, D6S206E | 6p21.32 | 3132 | ENSG00000196301 | OTTHUMG00000031197 | 588 | Histocompatibility complex |
| HGNC:4962 | HLA-E | major histocompatibility complex, class I, E | Approved | gene with protein product | 6p22.1 | 3133 | ENSG00000204592 | OTTHUMG00000031155 | 588 | Histocompatibility complex | ||
| HGNC:4963 | HLA-F | major histocompatibility complex, class I, F | Approved | gene with protein product | 6p22.1 | 3134 | ENSG00000204642 | OTTHUMG00000031156 | 588 | Histocompatibility complex | ||
| HGNC:4964 | HLA-G | major histocompatibility complex, class I, G | Approved | gene with protein product | 6p22.1 | 3135 | ENSG00000204632 | OTTHUMG00000031157 | 588 | Histocompatibility complex | ||
| HGNC:4965 | HLA-H | major histocompatibility complex, class I, H (pseudogene) | Approved | pseudogene | 6p22.1 | 3136 | ENSG00000206341 | OTTHUMG00000031160 | 588 | Histocompatibility complex | ||
| HGNC:4967 | HLA-J | major histocompatibility complex, class I, J (pseudogene) | Approved | pseudogene | HLA-CDA12, D6S203 | CDA12, HLA-59 | 6p22.1 | 3137 | ENSG00000204622 | OTTHUMG00000031161 | 588 | Histocompatibility complex |
| HGNC:4969 | HLA-K | major histocompatibility complex, class I, K (pseudogene) | Approved | pseudogene | HLAK, HLA70 | HLA-70 | 6p22.1 | 3138 | ENSG00000230795 | OTTHUMG00000031162 | 588 | Histocompatibility complex |
| HGNC:4970 | HLA-L | major histocompatibility complex, class I, L (pseudogene) | Approved | pseudogene | HLA92, HLAL | HLA-92 | 6p22.1 | 3139 | ENSG00000243753 | OTTHUMG00000031164 | 588 | Histocompatibility complex |
| HGNC:19406 | HLA-N | major histocompatibility complex, class I, N (pseudogene) | Approved | pseudogene | HLA-30 | 6p22.1 | 267014 | ENSG00000224372 | OTTHUMG00000031167 | 588 | Histocompatibility complex | |
| HGNC:21196 | HLA-P | major histocompatibility complex, class I, P (pseudogene) | Approved | pseudogene | C6orf101, HLA-90 | dJ377H14.3 | 6p22.1 | 352963 | ENSG00000261548 | OTTHUMG00000172781 | 588 | Histocompatibility complex |
| HGNC:19395 | HLA-S | major histocompatibility complex, class I, S (pseudogene) | Approved | pseudogene | HLA-17 | 6p21.33 | 267015 | ENSG00000225851 | OTTHUMG00000031178 | 588 | Histocompatibility complex | |
| HGNC:23478 | HLA-T | major histocompatibility complex, class I, T (pseudogene) | Approved | pseudogene | HLA-16 | 6p22.1 | 352964 | ENSG00000231130 | OTTHUMG00000031232 | 588 | Histocompatibility complex | |
| HGNC:23477 | HLA-U | major histocompatibility complex, class I, U (pseudogene) | Approved | pseudogene | HLA-21 | Em:AB023056.13 | 6p22.1 | 352965 | ENSG00000228078 | OTTHUMG00000031245 | 588 | Histocompatibility complex |
| HGNC:23482 | HLA-V | major histocompatibility complex, class I, V (pseudogene) | Approved | pseudogene | HLA-75 | dJ377H14.4 | 6p22.1 | 352962 | ENSG00000181126 | OTTHUMG00000031277 | 588 | Histocompatibility complex |
| HGNC:23425 | HLA-W | major histocompatibility complex, class I, W (pseudogene) | Approved | pseudogene | HLA-80 | 6p22.1 | 352966 | ENSG00000235290 | OTTHUMG00000031242 | 588 | Histocompatibility complex | |
| HGNC:19385 | HLA-X | major histocompatibility complex, class I, X (pseudogene) | Approved | pseudogene | 6p21.3 | 267016 | 588 | Histocompatibility complex | ||||
| HGNC:33913 | HLA-Y | major histocompatibility complex, class I, Y (pseudogene) | Approved | pseudogene | HLA-BEL/COQ/DEL | 6p21.33 | 100127173 | 588 | Histocompatibility complex | |||
| HGNC:19394 | HLA-Z | major histocompatibility complex, class I, Z (pseudogene) | Approved | pseudogene | HLA-Z1 | 6p21.32 | 267017 | ENSG00000235301 | OTTHUMG00000031189 | 588 | Histocompatibility complex |