If you set up a new windows server 2008.
After deploy a asp.net mvc 4 web application to IIS. It not work when your URL not have ".". I search a long time, but I found it was a bug, microsoft have a hot fix to resolve this problem.
The hot fix file name is : Windows6.1-KB980368-x64.
More info is :
程序包：
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知识库文章编号：980368
语言：All (Global)
平台：x64
位置：(http://hotfixv4.microsoft.com/Windows%207/WindowsServer%202008%20R2/sp1/Fix305889/7600/free/407288_intl_x64_zip.exe)